Dopamine D1A Receptor Regulation of Phospholipase C Isoform

Dopamine D1A receptor regulation of phospholipase C isoform.

In LTK- cells stably transfected with rat D1A receptor cDNA, fenoldopam, a D1 agonist, increased phosphatidylinositol 4, 5-bisphosphate hydrolysis in a time-dependent manner. In the cytosol, phospholipase C (PLC) activity increased (50 +/- 7%) in 30 s, returned to basal level at 4 h, and decreased below basal values by 24 h; in the membrane, PLC activity also increased (36 +/- 13%) in 30 s, ret...

HIP-70: an isoform of phosphoinositol-specific phospholipase C-alpha.

Biology of Free Radicals D5 dopamine receptor regulation of phospholipase D

Zhiwei Yang, Laureano D. Asico, Peiying Yu, Zheng Wang, John E. Jones, Ren-kui Bai, David R. Sibley, Robin A. Felder, and Pedro A. Jose Department of Physiology and Biophysics, Department of Pediatrics, Institute for Molecular and Human Genetics, Georgetown University Medical Center, Washington, District of Columbia; National Institute Neurological Disorders and Stroke, Bethesda, Maryland; and ...

Selective inhibition of the renal dopamine subtype D1A receptor induces antinatriuresis in conscious rats.

Both dopamine D1-like (D1A and D1B) and D2-like (D2, D3, and D4) receptor subfamilies are present in the kidney. Blockade of the intrarenal D1-like receptor family is associated with natriuresis and diuresis. Because the D1A and D1B receptor subtypes are not distinguishable by currently available dopaminergic agents, their functional role remains undefined. In the present study, the effect of s...

Modulatory actions of dopamine on NMDA receptor-mediated responses are reduced in D1A-deficient mutant mice.

The role of D1 dopamine (DA) receptors in mediating the ability of DA to modulate responses attributable to activation of NMDA receptors was examined in mice lacking D1A dopamine receptors. Specifically, experiments were designed to test the hypothesis that the ability of DA to potentiate responses mediated by activation of NMDA receptors was attributable to activation of D1 receptors. Based on...